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KMID : 0371420221030030153
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Annals of Surgical Treatment and Research
2022 Volume.103 No. 3 p.153 ~ p.159
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The role of postoperative neutrophil-to-lymphocyte ratio as a predictor of postoperative major complications following total gastrectomy for gastric cancer
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Kwak Jae-Seung
Kim Sung-Gon
Lee Sang-Eok
Choi Won-Jun
Yoon Dae-Sung
Choi In-Seok
Moon Ju-Ik
Sung Nak-Song
Kwon Seong-Uk
Bae In-Eui
Lee Seung-Jae
Roh Seung-Jae
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Abstract
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Purpose: This study was performed to investigate the role of the perioperative neutrophil-to-lymphocyte ratio (NLR) as an early predictor of major postoperative complications after total gastrectomy for gastric cancer.
Methods: This single-center, retrospective study reviewed consecutive patients with gastric cancer who underwent total gastrectomy at a single institution from March 2009 to March 2021. The postoperative complications were graded according to the Clavien-Dindo classification. We analyzed the patient demographics and surgical outcomes according to the grade of postoperative complications in the major complications group (≥grade III) and the no major complications group (
Results: Out of 212 patients (mean age, 64.1 years; 152 male [71.7%]), 63 (29.7%) underwent minimally invasive surgery. Twenty-five (11.8%) were in the major complications group and 187 (88.2%) were in the no major complications group. There was a significant difference in the NLR on POD 2 (16.54 vs. 8.83, P = 0.033) between the 2 groups. According to the receiver operating characteristic curve for the NLR on POD 2, the cutoff was calculated to be 9.6. In multivariate analysis, an NLR on POD 2 of ≥9.6 and an American Society of Anesthesiologists physical status classification of ≥III were statistically significant predictors of major postoperative complications.
Conclusion: Determination of the NLR on POD 2 is a simple and useful method for the early prediction of major complications after total gastrectomy for gastric cancer.
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KEYWORD
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Biomarkers, Gastrectomy, Postoperative complications, Stomach neoplasms
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